Invitrogen™ beta Synuclein Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA118259

Catalog No. 01-670-512

Description

Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.

Specifications

• Antigen: beta Synuclein
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SNCB
• Gene Alias: AI838531; betaSYN; beta-synuclein; Phosphoneuroprotein 14; PNP 14; Sncb; synuclein beta; synuclein, beta
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Frozen), Western Blot
• Concentration: Conc. Not Determined
• Formulation: Whole serum with no preservative
• Gene Accession No.: Q16143, Q63754
• Gene Symbols: SNCB
• Immunogen: Synthetic peptide corresponding to residues I(108) E P L M E P E G S Y E D P P Q E(125) of human beta synuclein protein.
• Regulatory Status: RUO
• Gene ID (Entrez): 113893, 6620
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized