beta Tubulin Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
FEPA5145231	Invitrogen™ PA5145231	200 μL
FEPA5145232	Invitrogen™ PA5145232	20 μL

Description

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintenance. Mutations in the beta tubulin gene are the cause of congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated. The precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression. Ser-172 phosphorylation inhibits tubulin incorporation into microtubules.Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55 kDa subunits: alpha and Beta. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. Because beta-tubulin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting.

Specifications

• Antigen: beta Tubulin
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat, Canine, Bovine, Sheep, Pig, Horse, Chicken, Guinea Pig, Goat
• Gene Accession No.: A2AQ07, P04350, P07437, P09207, P09244, P09652, P09653, P32882, P69897, P85108, P99024, Q13509, Q13885, Q2HJ81, Q2KJD0, Q2T9S0, Q3KRE8, Q3ZBU7, Q3ZCM7, Q4QRB4, Q6B856, Q767L7, Q7TMM9, Q922F4, Q9BUF5, Q9BVA1, Q9CWF2, Q9D6F9, Q9ERD7, Q9H4B7
• Gene ID (Entrez): 100051013, 100056684, 100058421, 100065776, 100134983, 100152382, 100153507, 100295973, 100303606, 100623583, 100629875, 100713236, 100718713, 100720651, 100731652, 100732882, 100733481, 100736584, 100855815, 101106224, 101115144, 102154194, 102168953, 102178062, 102178409, 102188330, 10381, 10382, 105609865, 106509340, 108633269, 203068, 22151, 22152, 22153, 22154, 246118, 281555, 291081, 29213, 29214, 307351, 347688, 347733, 396254, 396427, 420883, 421037, 431043, 474830, 478702, 480213, 485950, 498736, 534206, 540236, 541271, 545486, 615087, 679312, 67951, 7280, 733686, 73710, 768070, 768337, 81027, 84617
• Immunogen: Recombinant Human TUBb protein, Val170-Val419 (Accession #P07437).
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Alias: 2310057H16Rik; 2810484G07Rik; 3200002H15Rik; AA408537; AI325297; AI596182; B130022C14Rik; bA631M21.2; BB220206; beta 5-tubulin; beta Ib tubulin; beta tubulin; beta tubulin 1; beta-4; beta-4 tubulin; beta-4-tubulin; beta-5; beta-5 tubulin; beta5-tubulin; betaIII-tubulin; beta-tubulin; beta-tubulin class-III; Beta-tubulin class-V; beta-tubulin class-VI; Beta-tubulin isotype I; c(beta)7 tubulin; CDCBM; CDCBM1; CDCBM5; CDCBM6; CFEOM3; CFEOM3A; class I beta tubulin; Class I beta-tubulin; class IIa beta-tubulin; class III beta-tubulin; class IVa beta-tubulin; class V beta tubulin; class V beta-tubulin; CSCSC1; dJ40E16.7; dystonia 4, torsion (autosomal dominant); DYT4; FEOM3; HSA10p15 beta-tubulin 4Q; HsT1601; hypothetical protein LOC540236; hypothetical protein LOC550458; I79_000194; I79_012097; LOC100349792; LOC100761889; LOW QUALITY PROTEIN: tubulin beta-6 chain; M(beta)1; M(beta)2; M(beta)3; M(beta)4; M(beta)5; M(beta)6; M40; M40 antibody; MGC128415 protein; MGC137802 protein; neuron-specific class III beta-tubulin; OK/SW-cl.56; OOMD; OOMD2; RGD1305887; si:ch211-122i22.4; si:ch211-9a18.2; Tubb; tubb beta-5; tubb.L; Tubb1; TUBB2; Tubb2a; tubb2a {ECO:0000250; Tubb3; TUBB4; TUBB4A; tubb5; TUBB-5; TUBB6; TUBB8; Tubulin 5 beta; tubulin beta; tubulin beta 1 class VI; tubulin beta 2A class IIa; tubulin beta 3 class III; tubulin beta 4'; tubulin beta 4A class IVa; tubulin beta 6 class V; tubulin beta 8 class VIII; Tubulin beta chain; tubulin beta class I; tubulin beta class I L homeolog; Tubulin beta class IIa; Tubulin beta class V; tubulin beta MGC4083; tubulin beta-1; tubulin beta-1 chain; tubulin beta-1 chain-like; tubulin beta-2A chain; tubulin beta-2B chain; tubulin beta-3 chain; Tubulin beta-4 chain; tubulin beta-4A chain; Tubulin beta-5 chain; tubulin beta-5 chain; tubulin beta-6 chain; tubulin beta-6 chain; Tubulin beta-7 chain; tubulin beta-8 chain; Tubulin beta-III; tubulin, beta 1 class VI; tubulin, beta 2; tubulin, beta 2A; tubulin, beta 2A class IIA; tubulin, beta 3; tubulin, beta 3 class III; tubulin, beta 4; tubulin, beta 4 class IVa; tubulin, beta 4A class IVa; tubulin, beta 5; tubulin, beta 5 class I; tubulin, beta 6 class V; tubulin, beta class I; tubulin, beta family 1; tubulin, beta polypeptide; tubulin, beta polypeptide 2; tubulin, beta, 3; tubulin, beta, 4; tubulin, beta, 5; uncharacterized protein LOC550458; UniProtKB:Q7TMM9}; Unknown (protein for MGC:134115); unnamed protein product; XELAEV_18039222mg; XLOT; zbetaI; zgc:112515
• Gene Symbols: TUBB, Tubb1, Tubb2a, TUBB2B, Tubb3, Tubb4a, Tubb5, Tubb6, TUBB8
• Isotype: IgG
• Purification Method: Protein A
• Gene: Tubb4a