Bexarotene, 98%, PROMO, Thermo Scientific Chemicals

Description

Synthetic retinoid analog with specific affinity for the retinoid X receptor

Applications

Bexarotene is used as a Synthetic retinoid analog with specific affinity for the retinoid X receptor, an antineoplastic agent, already approved as an oral antineoplastic agent for cutaneous T cell lymphoma and being investigated against other cancers. A study has found that bexarotene in a mouse Alzheimer's model lowered the most toxic form of B-amyloid peptide and increased cognitive ability.

Solubility

Soluble in DMSO and ethanol

Notes

Store in cool, dry conditions in well sealed containers. Keep container tightly closed.

Specifications

Chemical Identifiers

• CAS: 153559-49-0
• Molecular Formula: C24H28O2
• Molecular Weight (g/mol): 348.49 g/mol
• MDL Number: MFCD00932428
• InChI Key: NAVMQTYZDKMPEU-UHFFFAOYSA-N
• Synonym: bexarotene, targretin, targrexin, targretyn, targret, bexarotenum, bexarotene usan, bexaroteno, bexaroten, targretin-gel
• PubChem CID: 82146
• ChEBI: CHEBI:50859
• IUPAC Name: 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid
• SMILES: CC1=CC2=C(C=C1C(=C)C1=CC=C(C=C1)C(O)=O)C(C)(C)CCC2(C)C

• Melting Point: 220°C to 225°C
• Color: White
• Quantity: 100 mg
• Merck Index: 14,1194
• Solubility Information: Soluble in DMSO and ethanol
• Percent Purity: ≥99%
• Physical Form: Powder
• Chemical Name or Material: Bexarotene

Safety and Handling

RTECSNumber	DH6834830
TSCA	No
Recommended Storage	Store at -20°C

RUO - Research Use Only