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Invitrogen™ BHLHE41 Polyclonal Antibody
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Catalog No. PIPA565992
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100 μL
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PIPA565992 100 μL
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Catalog No. PIPA565992 Supplier Invitrogen™ Supplier No. PA565992
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PFCLPFCFLSP SAAAAYVQPF LDKSGLEKYL YPAAAAAPFP LLY Highest antigen sequence identity to the following orthologs - mouse 86%, rat 45%.

The BHLHE41 gene encodes a basic helix-loop-helix (bHLH) transcription factor located at the 12p12.1 susceptibility locus. It functions primarily as a nuclear transcriptional repressor, homodimerizing or heterodimerizing with various partners to regulate gene expression. BHLHE41 expression is highly tissue-specific and responsive to environmental cues. Genetic studies have highlighted its role in increasing xenograft tumor growth and its involvement in short sleep phenotypes. A notable mutation in BHLHE41 leads to a phenotype requiring only six hours of sleep, demonstrating its influence on sleep patterns. Moreover, BHLHE41 has been associated with osteoclast differentiation processes, indicating its involvement in cellular development. Its interaction with TFEB target genes suggests a protective role against certain types of cell death, emphasizing its complex role in cellular physiology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BHLHE41
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Bhlhe41
Gene Accession No. Q9C0J9
Gene Alias 2-Dec; 6430520M22Rik; basic helix-loop-helix domain containing, class B, 3; basic helix-loop-helix domain containing, class B3; basic helix-loop-helix family member e41; basic helix-loop-helix family, member e41; bHLH transcriptional factor Dec2; Bhlhb2l; Bhlhb3; bHLHe41; Class B basic helix-loop-helix protein 3; class E basic helix-loop-helix protein 41; Dec2; differentially expressed in chondrocytes protein 2; Enhancer-of-split and hairy-related protein 1; hDEC2; mDEC2; SHARP1; SHARP-1
Gene Symbols Bhlhe41
Host Species Rabbit
Immunogen Recombinant Human BHLH3. Recombinant protein control fragment (Product #RP-106677).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79365
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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