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Invitrogen™ BHLHE41 Polyclonal Antibody
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Catalog No. PIPA568606
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100 μL
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PIPA568606 100 μL
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Catalog No. PIPA568606 Supplier Invitrogen™ Supplier No. PA568606
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%.

The BHLHE41 gene encodes a basic helix-loop-helix (bHLH) transcription factor located at the 12p12.1 susceptibility locus. It functions primarily as a nuclear transcriptional repressor, homodimerizing or heterodimerizing with various partners to regulate gene expression. BHLHE41 expression is highly tissue-specific and responsive to environmental cues. Genetic studies have highlighted its role in increasing xenograft tumor growth and its involvement in short sleep phenotypes. A notable mutation in BHLHE41 leads to a phenotype requiring only six hours of sleep, demonstrating its influence on sleep patterns. Moreover, BHLHE41 has been associated with osteoclast differentiation processes, indicating its involvement in cellular development. Its interaction with TFEB target genes suggests a protective role against certain types of cell death, emphasizing its complex role in cellular physiology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BHLHE41
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene Bhlhe41
Gene Accession No. 0
Gene Alias 2-Dec; 6430520M22Rik; basic helix-loop-helix domain containing, class B, 3; basic helix-loop-helix domain containing, class B3; basic helix-loop-helix family member e41; basic helix-loop-helix family, member e41; bHLH transcriptional factor Dec2; Bhlhb2l; Bhlhb3; bHLHe41; Class B basic helix-loop-helix protein 3; class E basic helix-loop-helix protein 41; Dec2; differentially expressed in chondrocytes protein 2; Enhancer-of-split and hairy-related protein 1; hDEC2; mDEC2; SHARP1; SHARP-1
Gene Symbols Bhlhe41
Host Species Rabbit
Immunogen synthetic peptide directed towards the middle region of human BHLH3.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117095
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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