Bi-1 Monoclonal Antibody (20F248), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA141678

Catalog No. 01-676-623

Description

MA1-41678 is derived from a mixture of three synthetic peptides corresponding to the N-terminal, internal and C-terminal regions of human B1.  Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of Bi-1.

BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007).  BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli.  Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress–causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury.  Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER.   

Specifications

• Antigen: Bi-1
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Gene: TMBIM6
• Gene Alias: BAXI1, BI-1, TEGT
• Host Species: Mouse
• Purification Method: IgM
• Regulatory Status: RUO
• Gene ID (Entrez): 7009
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: 20F248
• Conjugate: Unconjugated
• Gene Accession No.: P55061
• Gene Symbols: TMBIM6
• Immunogen: A mixture of three synthetic peptides corresponding to the N-terminal, internal and C-terminal regions of human Bax inhibitor 1.
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgM

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov