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Bi-1 Monoclonal Antibody (20F248), Invitrogen™

Catalog No. 01676623
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0.1 mL
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Catalog No. Quantity
01-676-623 0.1 mL
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Catalog No. 01-676-623 Supplier Thermo Scientific Supplier No. MA141678

Description

Mouse Monoclonal Antibody

MA1-41678 is derived from a mixture of three synthetic peptides corresponding to the N-terminal, internal and C-terminal regions of human B1.  Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of Bi-1.

BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007).  BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli.  Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress–causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury.  Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, it is thought to involve regulation of Ca2+ handling by the ER.   
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bi-1
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
Classification Monoclonal
Clone 20F248
Concentration 1.0 mg/mL
Conjugate Unconjugated
Gene TMBIM6
Gene Accession No. P55061
Gene Alias BAXI1, BI-1, TEGT
Gene Symbols TMBIM6
Host Species Mouse
Immunogen A mixture of three synthetic peptides corresponding to the N-terminal, internal and C-terminal regions of human Bax inhibitor 1.
Purification Method IgM
Quantity 0.1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7009
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgM
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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