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Invitrogen™ Bi-1 Polyclonal Antibody
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Catalog No. PIPA582588
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100 μL
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PIPA582588 100 μL
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Catalog No. PIPA582588 Supplier Invitrogen™ Supplier No. PA582588
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MNIFDRKINF DALLKFSHIT PSTQQHLKK Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 100%.

BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, itis thought to involve regulation of Ca2+ handling by the ER.
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Specifications

Antigen Bi-1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TMBIM6
Gene Accession No. P55061
Gene Alias 5031406P05Rik; Ab1-011; Ac1-149; Bax inhibitor 1; Bax inhibitor-1; BAXI1; Bi1; BI-1; Cc1-27; Tegt; testis enhanced gene transcript; testis-enhanced gene transcript protein; Tmbim6; transmembrane BAX inhibitor motif containing 6; transmembrane BAX inhibitor motif-containing protein 6
Gene Symbols TMBIM6
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TMBIM6. Recombinant protein control fragment (Product #RP-91281).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7009
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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