Invitrogen™ BICD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520555

Catalog No. PIPA520555

Description

A suggested positive control is Daudi cell lysate. PA5-20555 can be used with blocking peptide PEP-0675.

BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.

Specifications

• Antigen: BICD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BICD1
• Gene Alias: B830009D06Rik; bicaudal D homolog 1; bicaudal D homolog 1 (Drosophila); BICD; bic-D 1; BICD cargo adaptor 1; BICD1; cytoskeleton-like bicaudal D protein homolog 1; protein bicaudal D homolog 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12121, 362466, 636
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8BR07, Q96G01
• Gene Symbols: BICD1
• Immunogen: A 15 amino acid peptide from near the carboxy terminus of human BICD1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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