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BID Monoclonal Antibody (OTI2H9), TrueMAB™, OriGene
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA506759

Encompass_Preferred

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Catalog No. 50-167-6754


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Description

Description

BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.
Specifications

Specifications

BID
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P55957
BID
Full length human recombit protein of human BID produced in HEK293T cell.
100 μL
Primary
Human
Antibody
IgG2b
Immunocytochemistry, Immunofluorescence, Western Blot
OTI2H9
Unconjugated
BID
FP497
Mouse
Affinity Chromatography
RUO
637
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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