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BID Mouse anti-Human, Clone: OTI3A10, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF506767

Encompass_Preferred

Catalog No. 50-166-4440


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.
Specifications

Specifications

BID
Monoclonal
Unconjugated
BID
FP497
Mouse
Affinity Chromatography
RUO
637
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI3A10
PBS with 8% trehalose and no preservative; pH 7.3
P55957
BID
Full length human recombit protein of human BID produced in HEK293T cell.
100 μg
Primary
Human
Antibody
IgG2a
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