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BID Mouse anti-Human, Clone: OTI3A10, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF506767

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.Specifications
BID | |
Monoclonal | |
Unconjugated | |
BID | |
FP497 | |
Mouse | |
Affinity Chromatography | |
RUO | |
637 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
OTI3A10 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
P55957 | |
BID | |
Full length human recombit protein of human BID produced in HEK293T cell. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2a |
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