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Invitrogen™ Biliverdin Reductase Polyclonal Antibody

Catalog No. PIPA5122199
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200 μL
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PIPA5122199 20 μL
PIPA5118982 200 μL
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Catalog No. PIPA5122199 Supplier Invitrogen™ Supplier No. PA5122199
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Description

Rabbit Polyclonal Antibody

Biliverdin Reductase Polyclonal Antibody for Western Blot, IHC (P)

Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, an enzyme that converts heme to iron, carbon monoxide, and biliverdin. BLVR is unique among all enzymes to date in being dual pH/dual cofactor-dependent, as it requires NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor. There are two isoforms of BLVR, biliverdin-IX alpha-reductase (BLVRA), the major component of human adult liver, and biliverdin-IX beta-reductase (BLVRB), found predominantly in fetal liver. The product of BLVR, bilirubin, is an important biological antioxidant, however it is also a neurotoxin and the cause of kernicterus. In addition to being an antioxidant, it inhibits kinase activity and the activity of enzymes such as protein kinase C and NADPH oxidase.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Biliverdin Reductase
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.55 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene Blvra
Gene Accession No. P46844
Gene Alias 0610006A11Rik; 2500001N03Rik; Biliverdin reductase A; biliverdin reductase A-like protein; biliverdin-IX alpha-reductase; BLVR; Blvra; BVR; BVR A; BVRA; EC 1.3.1.24; testis tissue sperm-binding protein Li 61n
Gene Symbols Blvra
Host Species Rabbit
Immunogen Recombinant protein Biliverdin Reductase A. The antigen corresponds to amino acid range 10-279 of the target protein.
Purification Method Antigen affinity chromatography, Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116599
Target Species Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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