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Invitrogen™ Biliverdin Reductase Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5110854
Description
Immunogen sequence: EPERKFGVVV VGVGRAGSVR MRDLRNPHPS SAFLNLIGFV SRRELGSIDG VQQISLEDAL SSQEVEVAYI CSESSSHEDY IRQFLNAGKH VL.
Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, an enzyme that converts heme to iron, carbon monoxide, and biliverdin. BLVR is unique among all enzymes to date in being dual pH/dual cofactor-dependent, as it requires NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor. There are two isoforms of BLVR, biliverdin-IX alpha-reductase (BLVRA), the major component of human adult liver, and biliverdin-IX beta-reductase (BLVRB), found predominantly in fetal liver. The product of BLVR, bilirubin, is an important biological antioxidant, however it is also a neurotoxin and the cause of kernicterus. In addition to being an antioxidant, it inhibits kinase activity and the activity of enzymes such as protein kinase C and NADPH oxidase.
Specifications
Biliverdin Reductase | |
Polyclonal | |
Unconjugated | |
Blvra | |
0610006A11Rik; 2500001N03Rik; Biliverdin reductase A; biliverdin reductase A-like protein; biliverdin-IX alpha-reductase; BLVR; Blvra; BVR; BVR A; BVRA; EC 1.3.1.24; testis tissue sperm-binding protein Li 61n | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
644 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot, Immunocytochemistry | |
0.40 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P53004 | |
Blvra | |
Recombinant Protein corresonding to Human Biliverdin Reductase. Recombinant protein control fragment (Product #RP-92683). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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