Invitrogen™ Bim Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590693

Catalog No. PIPA590693

Description

Positive Samples: Raji, Jurkat, 293T, HeLa, mouse spleen; Cellular Location: Endomembrane system, Mitochondrion, Peripheral membrane protein Immunogen sequence: DTDRSPAPMS CDKSTQTPSP PCQAFNHYLS AMASMRQAEP ADMRPEIWIA QELRRIGDEF NAYYARRVFL NNYQAAEDHP RMVILRLLRY IVRLVWRMH.

BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Specifications

• Antigen: Bim
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BCL2L11
• Gene Alias: 1500006F24Rik; BAM; Bcl2 interacting mediator of cell death; bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; BCL2 like 11; Bcl-2 like 11; Bcl-2 related apoptotic gene product BimL; bcl2-interacting mediator of cell death; BCL2L11; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); bcl-2-like protein 11; bcl-2-like protein 11-like; bcl-2-related ovarian death agonist; bcl-2-related ovarian death protein; BIM; Bim EL; Bim-A; BIM-alpha6; BIM-beta6; BIM-beta7; BIMEL; BimEL protein; BimL; BOD; OTTHUMP00000197013; OTTHUMP00000204247; Unknown (protein for MGC:134444)
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10018, 12125, 64547
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 3.35 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O43521, O54918, O88498
• Gene Symbols: BCL2L11
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-198 of human Bim (NP_6195271).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG