BIN1 Monoclonal Antibody (99D), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA532996

Catalog No. PIMA532996

Description

Reconstitution information: Add 1 mL of PBS buffer will yield a concentration of 100 μg/mL.

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Specifications

• Antigen: BIN1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: BIN1
• Gene Alias: Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Bridging integrator 1; Bin1; Amph2, Amphl
• Host Species: Mouse
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Western Blot
• Clone: 99D
• Formulation: Ascites diluted in 1.2% sodium acetate with 2MG BSA, 2MG BSA and 0.01MG sodium azide, 0.01MG sodium azide
• Gene Accession No.: O00499, O08539, O08839
• Gene Symbols: Bin1
• Immunogen: Recombit polypeptide containing amino acids 189-398 of human Bin1.
• Regulatory Status: RUO
• Gene ID (Entrez): 117028, 274, 30948
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized