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MilliporeSigma™ Bin1, Mouse, Alexa Fluor 488, Clone: 99D,

Catalog No. 05449AFAMI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Alexa Fluor 488
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Catalog No. Quantity Conjugate
05449AFAMI 100 μL Alexa Fluor 488
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Catalog No. 05449AFAMI Supplier MilliporeSigma™ Supplier No. 05449AF488
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Description

Mouse Monoclonal Antibody

Myc box-dependent-interacting protein 1 (UniProt: O00499; also known as Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1, BIN1) is encoded by the BIN1 (also known as AMPHL) gene (Gene ID: 274) in human. BIN1 is expressed in many tissues, but has the highest expression in brain and muscle. In brain it is concentrated in the cytomatrix beneath the plasma membrane of axon initial segments and nodes of Ranvier. In skeletal muscle, it is concentrated around the plasmalemma of T tubules. BIN1 is involved in regulation of synaptic vesicle endocytosis and is also reported to act as a tumor suppressor that inhibits malignant cell transformation. BIN1 is considered as a dominant autoantigen in paraneoplastic Stiff-man syndrome. Mutations in BIN1 gene are known to cause myopathy centronuclear 2 (CNM2), a congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. Ref.: Butler, MH., et al., (1997). J. Cell Biol. 137(6): 1355 1367.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bin1
Applications Immunocytochemistry
Classification Monoclonal
Clone 99D
Concentration Please refer to lot specific datasheet.
Conjugate Alexa Fluor 488
Formulation Purified mouse monoclonal antibody IgG2b in PBS with 1.5% BSA and 0.05% Sodium Azide.
Gene BIN1, AMPHL
Gene Accession No. O00499
Host Species Mouse
Immunogen Linear peptide corresponding to human Bin1.
Purification Method Protein G Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Apoptosis & Cancer
Primary or Secondary Primary
Gene ID (Entrez) NP_004296.1
Test Specificity Clone 99D, Alexa Fluor™ 488 Conjugate detects Bin1 in A431 and HeLa cells by immunocytochemistry.
Target Species Chicken
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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For Research Use Only. Not for use in diagnostic procedures.

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