MilliporeSigma™ Bin1, Mouse, Alexa Fluor 488, Clone: 99D,
Mouse Monoclonal Antibody
Manufacturer: MilliporeSigma™ 05449AF488
DescriptionMyc box-dependent-interacting protein 1 (UniProt: O00499; also known as Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1, BIN1) is encoded by the BIN1 (also known as AMPHL) gene (Gene ID: 274) in human. BIN1 is expressed in many tissues, but has the highest expression in brain and muscle. In brain it is concentrated in the cytomatrix beneath the plasma membrane of axon initial segments and nodes of Ranvier. In skeletal muscle, it is concentrated around the plasmalemma of T tubules. BIN1 is involved in regulation of synaptic vesicle endocytosis and is also reported to act as a tumor suppressor that inhibits malignant cell transformation. BIN1 is considered as a dominant autoantigen in paraneoplastic Stiff-man syndrome. Mutations in BIN1 gene are known to cause myopathy centronuclear 2 (CNM2), a congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. Ref.: Butler, MH., et al., (1997). J. Cell Biol. 137(6): 1355 1367.
|Alexa Fluor 488|
|Linear peptide corresponding to human Bin1.|
|Protein G Purified|
|Stable for 1 year at 2°-8°C from date of receipt.|
|Clone 99D, Alexa Fluor™ 488 Conjugate detects Bin1 in A431 and HeLa cells by immunocytochemistry.|
|Please refer to lot specific datasheet.|
|Purified mouse monoclonal antibody IgG2b in PBS with 1.5% BSA and 0.05% Sodium Azide.|
|Apoptosis & Cancer|
|Chicken, Human, Mouse, Rat|
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For Research Use Only. Not for use in diagnostic procedures.