BIN1 Mouse anti-Human, Mouse, Clone:3B6F10, Abnova™

Catalog No.	Quantity
89-333-570	100 μg

Catalog No. 89-333-570 Supplier Abnova Corporation Supplier No. MAB17313

Description

Mouse monoclonal antibody raised against recombinant human BIN1.

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq]

Specifications

• Antigen: BIN1
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 3B6F10
• Conjugate: Unconjugated
• Description: bridging integrator 1
• Dilution: ELISA (1:10000)
  Flow Cytometry (1:200-400)
  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-1000)
  Western Blot (1:500-1:2000)
  The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% sodium azide)
• Gene: BIN1
• Gene Alias: AMPH2, AMPHL, DKFZp547F068, MGC10367, SH3P9
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 189-398 of of human BIN1 from E. coli.
• Quantity: 100 μg
• Gene ID (Entrez): 274
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b