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Invitrogen™ BIN1 Polyclonal Antibody
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Catalog No. PIPA595932
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100 μL
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PIPA595932 100 μL
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Catalog No. PIPA595932 Supplier Invitrogen™ Supplier No. PA595932
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QNLNDVLVGL EKQHGSNTFT VKAQPSDNAP AKGNKSPSPP DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQSSLPAV VVETFPATVN GTVEGGSGAG RLDLPPGFMF KVQAQHDYTA TDTDELQLKA GDVVLVIPFQ NPEEQDEGWL MGVKESDWNQ HKELEKCRGV FPENFTERVP; Positive Samples: SW620; Cellular Location: Cytoplasm, Nucleus.

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BIN1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.66 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene BIN1
Gene Accession No. O00499, O08839
Gene Alias ALP-1; AMPH 2; Amph2; amphiphysin 2; amphiphysin II; amphiphysin IIamph2; amphiphysin-like; amphiphysin-like protein; AMPHL; Bin1; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; BRAMP-2; bridging integrator 1; DKFZp547F068; MGC10367; MGC105358; myc box dependent interacting protein 1; myc box-dependent-interacting protein 1; SH3 domain-containing protein 9; SH3P9; similar to bridging integrator 1 isoform 9
Gene Symbols BIN1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 230-409 of human BIN1 (NP_6476011).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117028, 274
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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