Invitrogen™ BIN1 Recombinant Rabbit Monoclonal Antibody (JE34-92)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544806

Catalog No. PIMA544806

Description

BIN1 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Specifications

• Antigen: BIN1
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: O00499, O08839
• Gene Symbols: BIN1
• Immunogen: Recombinant protein within human BIN1 aa 394-593/593.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: JE34-92
• Conjugate: Unconjugated
• Gene: BIN1
• Gene Alias: ALP-1; AMPH 2; Amph2; amphiphysin 2; amphiphysin II; amphiphysin IIamph2; amphiphysin-like; amphiphysin-like protein; AMPHL; Bin1; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; BRAMP-2; bridging integrator 1; DKFZp547F068; MGC10367; MGC105358; myc box dependent interacting protein 1; myc box-dependent-interacting protein 1; SH3 domain-containing protein 9; SH3P9; similar to bridging integrator 1 isoform 9
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 117028, 274
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov