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  5. Tocris Bioscience™ BIO 5192

Tocris Bioscience™ BIO 5192
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Catalog No. 505110
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10 mg
50 mg
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Catalog No. Quantity
50-511-0 10 mg
50-515-0R 50 mg
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Catalog No. 50-511-0 Supplier Tocris Bioscience™ Supplier No. 5051/10
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Description

Highly potent and selective inhibitor of integrin α4β1

BIO 5192 is a highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM). Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.

Specifications

Quantity 10 mg
Product Type BIO 5192
Purity >98%
Molecular Weight (g/mol) 817.78
Inhibitors BIO 5192

For Research Use Only

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