Tocris Bioscience™ BIO 5192

Description

Highly potent and selective inhibitor of integrin α4β1

BIO 5192 is a highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM). Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.

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Specifications

• Quantity: 50 mg
• Product Type: BIO 5192
• Purity: >98%
• Molecular Weight (g/mol): 817.78
• Inhibitors: BIO 5192

For Research Use Only