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BIRC6/Apollon Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A300367A

Encompass_Preferred

Catalog No. 50-155-7472


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
Specifications

Specifications

BIRC6/Apollon
Polyclonal
Unconjugated
BIRC6
BRUCE, Baculoviral IAP repeat containing 6, BIRC6, APOLLON
Rabbit
Antigen affinity chromatography
RUO
12211, 57448
4° C
Liquid
Immunohistochemistry, Immunoprecipitation, Western Blot
1 mg/ml
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
O88738, Q9NR09
BIRC6
Between 4775 and C-term
100 μL
Primary
Human, Mouse
Antibody
IgG
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