Invitrogen™ Bit1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA592996

Catalog No. PIPA592996

Description

Immunogen sequence: LPKSKTSKTH TDTESEASIL GDSGEYKMIL VVRNDLKMGK GKVAAQCSHA AVSAYKQIQR RNPEMLKQWE YCGQPKVVVK APDEETLIAL LAHAKMLGLT VSLIQDAGRT QIAPGSQTVL GIGPGPADLI DKVTGHLKLY; Positive Samples: MCF7, BT-474, SW480, Mouse liver, Mouse spleen, Mouse thymus, Rat brain; Cellular Location: Mitochondrion.

The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: Bit1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ptrh2
• Gene Alias: A230072I16Rik; Bcl-2 inhibitor of transcription; bcl-2 inhibitor of transcription 1; BIT1; CFAP37; CGI-147; cilia and flagella associated protein 37; IMNEPD; OTTHUMP00000205936; peptidyl-tRNA hydrolase 2; peptidyl-tRNA hydrolase 2, mitochondrial; PTH; PTH 2; Pth2; Ptrh2; RGD1306819
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 217057, 287593, 51651
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.62 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8R2Y8, Q9Y3E5
• Gene Symbols: Ptrh2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-179 of human PTRH2 (NP_0571611).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG