Tocris Bioscience BIX 02189
Selective MEK5 and ERK5 inhibitor
Manufacturer: Tocris Bioscience 4842/10
DescriptionSelective MEK5 and ERK5 inhibitor (IC50 values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.
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