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  5. Tocris Bioscience™ BIX NHE1 inhibitor

Tocris Bioscience™ BIX NHE1 inhibitor
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Catalog No. 551250
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55-125-0 50 mg
55-121-0 10 mg
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Catalog No. 55-125-0 Supplier Tocris Bioscience™ Supplier No. 5512/50
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Description

Potent and selective NHE1 inhibitor

BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine -induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

Specifications

Chemical Name or Material 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride
CAS 1422252-46-7
Quantity 50 mg
Target Na+/Ca2+ Exchanger Inhibitors
Molecular Formula C16H19F3N4O2.HCl
Formula Weight 392.8
Purity >98%
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