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Invitrogen™ BK Virus VP1 Monoclonal Antibody (4943)
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Catalog No. PIMA533243
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PIMA533243 1 mL
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Catalog No. PIMA533243 Supplier Invitrogen™ Supplier No. MA533243
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Description

Mouse Monoclonal Antibody

BK Virus VP1 Monoclonal Antibody for ICC/IF, ELISA

BK Virus VP1 forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with gangliosides GT1b and GD1b containing terminal alpha2-8-linked sialic acids on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BK Virus VP1
Applications ELISA, Immunocytochemistry
Classification Monoclonal
Clone 4943
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.2
Gene Alias BKV; BKV VP1
Host Species Mouse
Purification Method Protein A
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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