Invitrogen™ Blood Group H Antigen Monoclonal Antibody (89-8)

Catalog No.	Quantity
01-670-408	100 μg

Catalog No. 01-670-408 Supplier Invitrogen™ Supplier No. MA17674

Description

Mouse Monoclonal Antibody

MA1-7674 detects H1 and H2 human blood from human samples. MA1-7674 has been successfully used in ELISA and agglutination applications. The MA1-7674 immunogen is a H human blood protein. For short term storage, store product at 4ºC. For long-term storage, store at -80ºC.

The H antigen is a precursor to the ABO blood groupantigens, present in people of all common blood types. The Bombay phenotype (hh) does not express antigen H on red blood cells, and therefore this type will also lack A or B antigens, similar to the O blood group. However, unlike O group, the H antigen is absent, hence the individuals produce isoantibodies to antigen H as well as to both A and B antigens. If they receive blood from someone with O blood group, the anti-H antibodies will bind to the H antigen on the red blood cells of the donor blood and destroy the RBCs bycomplement-mediated lysis. Therefore, people with Bombay phenotype can receive blood only from otherhhdonors, although they can donate as though they were type O. Some individuals with the blood group A1 may also be able to produce anti-H antibodies due to the complete conversion of all the H antigen to A1 antigen. Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19. The H locus contains threeexonsthat span more than 5kbof genomic DNA, and encodes thefucosyltransferasethat produces the H antigen on RBCs. The H antigen is a carbohydrate sequence withcarbohydrateslinked mainly to protein (with a minor fraction attached toceramidemoiety).

Specifications

• Antigen: Blood Group H Antigen
• Applications: Agglutination, ELISA
• Classification: Monoclonal
• Clone: 89-8
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.01% sodium azide; pH 7.2
• Gene Alias: ABH; BG-H; BG-H1; group h
• Host Species: Mouse
• Immunogen: H human blood protein.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: 4°C short term, -80°C long term
• Product Type: Antibody
• Form: Liquid
• Isotype: IgM