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Invitrogen™ BLOS1 Polyclonal Antibody
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Catalog No. PIPA5109347
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100 μL
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PIPA5109347 100 μL
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Catalog No. PIPA5109347 Supplier Invitrogen™ Supplier No. PA5109347
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Description

Rabbit Polyclonal Antibody

Positive Control: Rice tissue lysates, A. thaliana tissue.

Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that mediates the vacuolar degradative transport via the intracellular vesicle trafficking from the endosome to the vacuole. Probably regulates the PIN1 and PIN2 homeostasis through its interaction with SNX1. An eight-subunit protein complex, BLOC-1, which is involved in endosomal transport from the endosomes to the lysosomes, has been identified in both human and mice. In this study, two homologous subunits of this complex, BLOS1 (or AtGCN5L1) and BLOS2, have been characterized in Arabidopsis. Both BLOS1 and BLOS2 interacted with SNX1 on the sorting endosomes. Inducible RNAi lines with reduced levels of BLOS1 had longer primary roots and more lateral roots. Consistently, PIN1 and PIN2 were increased in BLOS1 RNAi lines, implicating an impaired transport from the endosomes to the vacuoles. These results suggest that a putative BLOC-1 complex in Arabidopsis might mediate the vacuolar degradative transport through direct interaction with SNX1 to regulate the homeostasis of PIN1 and PIN2, which is important for plant growth and development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BLOS1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
Gene BLOS1
Gene Accession No. O22929
Gene Alias At2g30330; Biogenesis of lysosome-related organelles complex 1 subunit 1; BLOC subunit 1; BLOC-1 subunit 1; BLOS1; GCN5L1; GCN5L1 family protein; GCN5-like protein 1; Protein RT14 homolog; T09D09.14; T9D9.14; T9D9_14; unknown protein
Gene Symbols BLOS1
Host Species Rabbit
Immunogen Synthetic peptide within thaliana BLOS1 aa 26-75.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 817583
Target Species Plant
Content And Storage -20°C, Avoid Freeze/Thaw Cycles, store in dark
Product Type Antibody
Form Liquid
Isotype IgG
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