Invitrogen™ BMI-1 Polyclonal Antibody, DyLight™ 550

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522848

Catalog No. PIPA522848

Description

Suggested positive control: human and mouse skeletal muscle. Immunogen sequence homology: primate, feline, chicken, bovine, rabbit, rat and Zebrafish protein (all 92%).

Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Specifications

• Antigen: BMI-1
• Classification: Polyclonal
• Conjugate: DyLight 550
• Gene: BMI1
• Gene Alias: AW546694; B lymphoma Mo-MLV insertion region 1; B lymphoma Mo-MLV insertion region 1 homolog; Bmi1; Bmi-1; BMI1 polycomb ring finger oncogene; BMI1 polycomb ring finger proto-oncogene; BMI1 proto-oncogene, polycomb ring finger; FLVI2/BMI1; flvi-2/bmi-1; murine leukemia viral (bmi-1) oncogene homolog; Pcgf4; Pcgf4 antibody; Polycomb complex protein BMI-1; polycomb group protein Bmi1; polycomb group ring finger 4; polycomb group RING finger protein 4; RING finger protein 51; RNF51; RP11-573G6.1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12151, 648
• Content And Storage: 4°C, store in dark
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 0.83 mg/mL
• Formulation: 50mM sodium borate with 0.05% sodium azide
• Gene Accession No.: P25916, P35226
• Gene Symbols: BMI1
• Immunogen: A synthetic peptide made to an internal region (within residues 1-100) of human Bmi1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG