BMI1 Mouse anti-Human, Mouse, Non-human primate, Clone: 2E10A11, Proteintech

Catalog No.	Quantity
50-173-6595	150 μL

Catalog No. 50-173-6595 Supplier Proteintech Group Inc Supplier No. 661611IG150UL

Description

Mouse Monoclonal Antibody

The antibody reacts with the 37 kDa BMI1 protein.

The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas. BMI-1 is involved in segment specification, cell growth and maintece, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence. Recent studies have also shown that BMI-1 is required for the maintece of adult normal and leukemic stem cells, suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.

Specifications

• Antigen: BMI1
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 2E10A11
• Concentration: 0.57 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: BMI1
• Gene Accession No.: P25916, P35226
• Gene Alias: BMI1, PCGF4, Polycomb complex protein BMI 1, RING finger protein 51, RNF51
• Gene Symbols: BMI1
• Host Species: Mouse
• Immunogen: BMI1 Fusion Protein Ag21284
• Purification Method: Protein A
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12151, 648
• Target Species: Human, Mouse, Non-human Primate
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b