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Invitrogen™ BMP-10 Monoclonal Antibody (A1), Invitrogen™

Catalog No. PIMA543938
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100 μL
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PIMA543938 20 μL
PIMA543937 100 μL
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Catalog No. PIMA543938 Supplier Invitrogen™ Supplier No. MA543938
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Description

Mouse Monoclonal Antibody

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BMP-10
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone A1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene BMP10
Gene Accession No. O95393
Gene Alias BMP; BMP10; BMP-10; bmp10 {ECO:0000312; bmp10b; Bone morphogenetic protein; bone morphogenetic protein 10; EMBL:BAE16990.1, ECO:0000312; RGD:1562986}; si:dkey-13n15.5
Gene Symbols BMP10
Host Species Mouse
Immunogen Arg315-Arg424 (Accession O95393), with N-terminal His and GST Tag.
Purification Method Protein A/G
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27302
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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