Invitrogen™ BMP-8B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA577881

Catalog No. PIPA577881

Description

Positive Control: U87-MG, SK-N-SH, IMR32, SK-N-AS, human BMP8B-transfected 293T, mouse brain Predicted reactivity: Human (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

BMP-8B encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. BMP-8B may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1.

Specifications

• Antigen: BMP-8B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Bmp8b
• Gene Alias: BMP; BMP8; BMP-8; Bmp8b; BMP-8B; Bone morphogenetic protein; bone morphogenetic protein 8 (osteogenic protein 2); bone morphogenetic protein 8B; dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)); MGC131757; OP2; OP-2; Op3; Osteogenic protein 2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 656
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P34820
• Gene Symbols: Bmp8b
• Immunogen: Recombinant protein encompassing a sequence within the center region of human BMP8b. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG