Invitrogen™ BMPR1A Monoclonal Antibody (4B7B2)

Catalog No.	Quantity
PIMA517036	100 μg

Catalog No. PIMA517036 Supplier Invitrogen™ Supplier No. MA517036

Description

Mouse Monoclonal Antibody

MA5-17036 targets BMPR1A in indirect ELISA, FACS, IHC and WB applications and shows reactivity with Human samples. The MA5-17036 immunogen is purified recombinant fragment of human BMPR1A (amino acids: 179-378 ) expressed in E. Coli. MA5-17036 detects BMPR1A which has a predicted molecular weight of approximately 60kDa.

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Specifications

• Antigen: BMPR1A
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 4B7B2
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% sodium azide
• Gene: BMPR1A
• Gene Accession No.: P36894
• Gene Alias: 10q23del; 1110037I22Rik; activin A receptor, type II-like kinase 3; activin receptor-like kinase 3; ACVRLK3; ALK3; ALK-3; AU045487; BMP type-1A receptor; BMP-2/BMP-4 receptor; Bmpr; Bmpr1a; BMPR-1A; BMPRIA; BMPR-IA; Bone morphogenetic protein 4 receptor; bone morphogenetic protein receptor type 1A; bone morphogenetic protein receptor type IA; bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type 1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5
• Gene Symbols: BMPR1A
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human BMPR1A (amino acids: 179-378 ) expressed in E. Coli.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 657
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1