BMPR2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-9409	150 μL

Catalog No. 50-172-9409 Supplier Proteintech Group Inc Supplier No. 143761AP150UL

Description

Rabbit Polyclonal Antibody

This antibody recognizes endogenous levels of total BMPR2 protein, including 115 kDa precursor, 75 kDa mature form and 150 kDa dimer.

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

Specifications

• Antigen: BMPR2
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.28 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: BMPR2
• Gene Accession No.: O35607, Q13873
• Gene Alias: BMP type 2 receptor, BMP type II receptor, BMPR 2, BMPR II, BMPR2, BMPR3, BMR2, BRK 3, PPH1, T ALK
• Gene Symbols: BMPR2
• Host Species: Rabbit
• Immunogen: BMPR2 Fusion Protein Ag5752
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12168, 140590, 659
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG