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Tocris Bioscience™ BMS 345541

Selective allosteric inhibitor of IKK; anti-inflammatory

Supplier:  Tocris Bioscience™ 4806/10

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Catalog No. 48-061-0


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Description

Description

BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.
Specifications

Specifications

>99%
BMS 345541
BMS 345541
10 mg
291.78
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