Tocris Bioscience BMS 345541
Selective allosteric inhibitor of IKK; anti-inflammatory
Manufacturer: Tocris Bioscience 4806/10
DescriptionSelective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.
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