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  5. Tocris Bioscience™ BMS 345541

Tocris Bioscience™ BMS 345541
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Catalog No. 480610
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Catalog No. Quantity
48-061-0 10 mg
48-065-0 50 mg
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Catalog No. 48-061-0 Supplier Tocris Bioscience™ Supplier No. 4806/10
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Description

Selective allosteric inhibitor of IKK; anti-inflammatory

BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

Specifications

Quantity 10 mg
Product Type BMS 345541
Purity >99%
Molecular Weight (g/mol) 291.78
Inhibitors BMS 345541

For Research Use Only

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