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BMS 536924, Tocris Bioscience™
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Quantity:
10 mg
Description
Dual inhibitor of the insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) (IC50 values are 73 and 100 nM respectively). Inhibits receptor autophosphorylation and downstream MEK1/2 and Akt signaling. Induces G1 arrest and apoptosis in ML-1 cells; also inhibits cell proliferation in multiple tumor types. Reverses EMT through the attenuation of Snail mRNA expression in MCF10A cell over expressing IGF1R.
Specifications
Specifications
Quantity | 10 mg |
Formula Weight | 479.96 |
Percent Purity | >98% |
Chemical Name or Material | BMS 536924 |
Safety and Handling
Recommended Storage | Store at -20°C |
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