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Invitrogen™ BNC1 Polyclonal Antibody
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Catalog No. PIPA566883
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100 μL
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PIPA566883 100 μL
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Catalog No. PIPA566883 Supplier Invitrogen™ Supplier No. PA566883
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: REVEDGGHEHY FTPGMEPQVP FSDYMELQQR LLAGGLFSAL SNRGMAFPCL EDSKELEHVG QHALARQIEE NRFQCD Highest antigen sequence identity to the following orthologs - mouse 79%, rat 77%.

Bnc 1 is a 994 amino acid transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. It is a zinc finger protein with three separated pairs of zinc fingers and a nuclear localization signal. Bnc 1 is a soluble protein that can shuttle between the nucleus and the cytoplasm, and its location depends on the proliferative potential of the cell. It is expressed relatively uniformly in the nucleoplasm, and phosphorylation on Ser-537 and Ser-541 leads to its cytoplasmic localization. It is present in the basal cell layer of the epidermis, in hair follicles and also in abundance in the germ cells of testis and ovary, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart. Reports suggest that it plays a regulatory role in keratinocyte proliferation and also in rRNA transcription. It is also known to play a role in the differentiation of spermatozoa and oocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BNC1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene BNC1
Gene Accession No. Q01954
Gene Alias AI047752; AW546376; basonuclin 1; BNC; bnc 1; Bnc1; BSN1; HsT19447; zinc finger protein basonuclin-1
Gene Symbols BNC1
Host Species Rabbit
Immunogen Recombinant Human BNC1. Recombinant protein control fragment (Product #RP-105411).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 646
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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