Invitrogen™ Bombesin Receptor 3 Polyclonal Antibody

Catalog No.	Quantity
APS302	100 μL

Catalog No. APS302 Supplier Invitrogen™ Supplier No. PA3302

Description

Rabbit Polyclonal Antibody

PA3-302 detects BRS3 from human samples. PA3-302 has been successfully used in Western blot and immunohistochemistry (paraffin) procedures. By Western blot, this antibody detects a ~50-70 kDa protein representing BRS3. The PA3-302 immunogen is a synthetic peptide corresponding to residues E(381) I S V T S F T G C S V K Q A E D R F(399) of human BRS3 protein.

BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: Bombesin Receptor 3
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: whole serum with 0.05% sodium azide
• Gene: BRS3
• Gene Accession No.: P32247
• Gene Alias: BB3; BB3R; bombesin like receptor 3; bombesin receptor subtype 3; bombesin receptor subtype-3; bombesin-like receptor 3; BRS 3; BRS3; BRS-3; G-protein coupled receptor; RP1-196E23.3
• Gene Symbols: BRS3
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues E(381) I S V T S F T G C S V K Q A E D R F(399) of human BRS3 protein.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 680
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG