Invitrogen™ Bombesin Receptor 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532677

Catalog No. PIPA532677

Description

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Mouse, Rat, Bovine, Dog, Hamster, Panda, Horse, Guinea pig (100%); Monkey, Marmoset, Sheep, Elephant, Rabbit (95%); Bat (85%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: Bombesin Receptor 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BRS3
• Gene Alias: BB3; BB3R; bombesin like receptor 3; bombesin receptor subtype 3; bombesin receptor subtype-3; bombesin-like receptor 3; BRS 3; BRS3; BRS-3; G-protein coupled receptor; RP1-196E23.3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100054718, 100135488, 100763382, 12209, 260319, 539011, 613002, 680
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: O54798, P32247, P35371, Q8K418
• Gene Symbols: BRS3
• Immunogen: Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human BRS3.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Bovine, Hamster, Horse, Guinea Pig
• Product Type: Antibody
• Isotype: IgG