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Invitrogen™ Bora Polyclonal Antibody
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Catalog No. PIPA520708
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100 μg
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Catalog No. Quantity
PIPA520708 100 μg
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Catalog No. PIPA520708 Supplier Invitrogen™ Supplier No. PA520708
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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse brain tissue lysate. PA5-20708 can be used with blocking peptide PEP-0823.

Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bora
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene BORA
Gene Accession No. Q5M864, Q6PGQ7, Q8BS90
Gene Alias 6720463M24Rik; AI317232; aurora borealis; BORA; bora, aurora kinase A activator; C13orf34; HsBora; Protein aurora borealis; RGD1309522; RP11-342J4.2
Gene Symbols BORA
Host Species Rabbit
Immunogen A 15 amino acid peptide from near the carboxy terminus of human Bora.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 306102, 77744, 79866
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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