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Invitrogen™ Bora Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA520709
Description
A suggested positive control is Jurkat cell lysate. PA5-20709 can be used with blocking peptide PEP-0824.
Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.
Specifications
Bora | |
Polyclonal | |
Unconjugated | |
BORA | |
6720463M24Rik; AI317232; aurora borealis; BORA; bora, aurora kinase A activator; C13orf34; HsBora; Protein aurora borealis; RGD1309522; RP11-342J4.2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
306102, 77744, 79866 | |
Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C | |
Liquid |
Immunohistochemistry, Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
Q5M864, Q6PGQ7, Q8BS90 | |
BORA | |
A 15 amino acid peptide from near the amino terminus of human Bora. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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