Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Invitrogen™ Bora Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520709

Catalog No. PIPA520709


Only null left
Add to Cart

Description

Description

A suggested positive control is Jurkat cell lysate. PA5-20709 can be used with blocking peptide PEP-0824.

Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Bora
Polyclonal
Unconjugated
BORA
6720463M24Rik; AI317232; aurora borealis; BORA; bora, aurora kinase A activator; C13orf34; HsBora; Protein aurora borealis; RGD1309522; RP11-342J4.2
Rabbit
Antigen affinity chromatography
RUO
306102, 77744, 79866
Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Liquid
Immunohistochemistry, Western Blot, Immunocytochemistry
1 mg/mL
PBS with 0.02% sodium azide
Q5M864, Q6PGQ7, Q8BS90
BORA
A 15 amino acid peptide from near the amino terminus of human Bora.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Product Certifications
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.