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Invitrogen™ Bora Polyclonal Antibody
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Catalog No. PIPA589480
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100 μL
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PIPA589480 100 μL
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Catalog No. PIPA589480 Supplier Invitrogen™ Supplier No. PA589480
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KYSLGSITSP SPISSPTFSP IEFQIGETPL SEQRKFTVHS PDASSGTNSN GITNPCIRSP YIDGCSPIKN WSPMRLQMYS GGTQYRTSVI QIPFTLETQG EDEEDKENIP STDVSSPAMD AAGIHLRQFS NEASTHGTHL VVTAMSVTQN QSSASEKELA LLQDVEREKD NNTVDMVDPI EIADETTWIK EPVDNGSLPM TDFVSGIAFS IENSHMCMSP LAESSVIPCE SSNIQMDSGY NTQNCGSNIM DTVGAESYCK ESDAQTCEVE SKSQAFNMKQ DHTTQRCWMK TASPFQCSSP; Positive Samples: HT-29, HeLa.

Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bora
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.97 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene BORA
Gene Accession No. Q6PGQ7
Gene Alias 6720463M24Rik; AI317232; aurora borealis; BORA; bora, aurora kinase A activator; C13orf34; HsBora; Protein aurora borealis; RGD1309522; RP11-342J4.2
Gene Symbols BORA
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 260-559 of human BORA (NP_079084.4).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79866
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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