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  5. Tocris Bioscience™ Bortezomib

Tocris Bioscience™ Bortezomib
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Catalog No. 72825
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25 mg
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Catalog No. Quantity
72-825 5 mg
72-822-5 25 mg
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Catalog No. 72-825 Supplier Tocris Bioscience™ Supplier No. 7282/5
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Description

High affinity proteasome inhibitor

Bortezomib is a high affinity proteasome inhibitor (Ki = 0.6 nM). Inhibits growth of multiple myeloma (MM) cell lines (IC50 values in <50 nM range); induces apoptosis in MM cell lines and MM patient derived cells, including p53 mutant cell lines. Decreases adherence of MM cells lines to bone marrow stromal cells (BMSCs). Acts synergistically with dexamethasone (Cat. No. 1126). Also cytotoxic in MCF-7 breast cancer cell line (IC50 = 50 nM).

Specifications

Chemical Name or Material B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
CAS 179324-69-7
Quantity 5 mg
Target Proteasome Inhibitors
Molecular Formula C19H25BN4O4
Purity 0.98
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