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Invitrogen™ Brachyury Monoclonal Antibody (X1AO2), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ 14977082

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Catalog No. 50-112-2852


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Description

Description

Description: The monoclonal antibody X1AO2 recognizes human Brachyury, a 47 kDa protein encoded by the T gene and functioning as a nuclear transcription factor. This transcription factor binds to specific DNA regions near the palindromic sequence TCACACCT (T-site) through a region in its N-terminus, called the T-box. Brachyury functions during embryogenesis to regulate midline development by establishing the anterior/posterior axis through the regulation of genes involved in mesoderm formation and differentiation. Brachyury is the primary mesoderm marker used to distinguish differentiation of embryonic stem cells into a mesenchymal stem cell lineage. Variations in the T gene in humans are associated with neural tube defects and chordomas. Expression of brachyury is also increased in advanced stage lung tumors and tumor cell lines. Applications Reported: This X1AO2 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, immunohistochemical staining, and immunocytochemistry. Applications Tested: This X1AO2 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded human tissue using low pH antigen retrieval and can be used at less than or equal to 5 μg/mL. This X1AO2 antibody has also been tested by immunocytochemistry of fixed and permeabilized human cells and can be used at less than or equal to 5 μg/mL.

The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Brachyury
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
O15178
TBXT
E.coli-derived fragment of human Brachyury corresponding to amino acids 237-348.
100 μg
Primary
Human
Antibody
IgG2b κ
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
X1AO2
Unconjugated
TBXT
Bra; brachyury; brachyury homolog; brachyury protein; brachyury-like 2; brachyury-like 3; cou; D17Mit170; Low; low ratio; Lr; me75; Protein T; RP11-459F1.1; SAVA; T; T brachyury homolog; T brachyury transcription factor; T, brachyury homolog; T1; T-box transcription factor T; TBXT; TFT; Tl2; Tl3
Mouse
Affinity chromatography
RUO
6862
4°C
Liquid
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