Invitrogen™ BRAP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA559145

Catalog No. PIPA559145

Description

Immunogen sequence: SLVVIRLELA EHSPVPAGFG FSAAAGEMSD EEIKKTTLAS AVACLEGKSP GEKVAIIHQH LGRREMTDVI IETMKSNPDE LKTTVEERKS SEA Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 83%.

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Specifications

• Antigen: BRAP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BRAP
• Gene Alias: 3010002G07Rik; BRAP; BRAP2; BRCA1 associated protein; BRCA1-associated protein; galectin-2-binding protein; IMP; Impedes mitogenic signal propagation; renal carcinoma antigen NY-REN-63; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; RNF52
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 687346, 72399, 8315
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q7Z569, Q99MP8
• Gene Symbols: BRAP
• Immunogen: Recombinant protein corresponding to Human BRAP. Recombinant protein control fragment (Product #RP-97663).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov