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BRCA1 Mouse anti-Human, Clone: OTI2A5, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF802628

Encompass_Preferred

Catalog No. 50-166-6076


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
Specifications

Specifications

BRCA1
Monoclonal
Unconjugated
BRCA1
BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53
Mouse
Affinity Chromatography
RUO
672
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI2A5
PBS with 8% trehalose and no preservative; pH 7.3
P38398
BRCA1
Human recombit protein fragment corresponding to amino acids 1151-1473 of human BRCA1 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG1
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