BRCA2 Mouse anti-Human, Clone: 9D3, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA531585

Catalog No. PIMA531585

Description

Keep as concentrated solution. Positive Control: HCT116. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintece of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Specifications

• Antigen: BRCA2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.2
• Gene Accession No.: P51587
• Gene Symbols: BRCA2
• Immunogen: BRCA2 protein fragment containing amino acids 2336-2478 of human BRCA2 expressed in E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 9D3
• Conjugate: Unconjugated
• Gene: BRCA2
• Gene Alias: 114480; FACD; FANCB; P51587; FANCD1; BRCC2; BRCA2; FANCD; 675; FAD1; FAD
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 675
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid