BRCC36 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-156-2788	Bethyl Laboratories, Inc A302517AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predict

Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity. Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage. Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors. At least two isoforms of BRCC36 are known to exist.

Specifications

• Antigen: BRCC36
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: RP11-143H17.2, BRCC36, C6.1A, CXorf53; BRCA1-A complex subunit BRCC36; BRCA1/BRCA2-containing complex subunit 36; BRISC complex subunit BRCC36; lys-63-specific deubiquitinase BRCC36
• Immunogen: Between 266 and 316
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: BRCC3

• Applications: Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: P46736, P46737
• Gene ID (Entrez): 210766, 79184
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody