BRCC45 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-6738	100 μL

Catalog No. 50-198-6738 Supplier Bioss Supplier No. BS5710R

Description

Rabbit Polyclonal Antibody

BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

Specifications

• Antigen: BRCC45
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: BABAM2
• Gene Accession No.: Q9NXR7
• Gene Alias: 6030405P19Rik; AI429776; B830038C02Rik; BABAM2; brain and reproductive organ-expressed (TNFRSF1A modulator); Brain and reproductive organ-expressed protein; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; BRCA1-A complex subunit BRE; BRCC4; BRCC45; BRE; bre {ECO:0000312; BRISC and BRCA1-A complex member 2; RGD:735111}
• Gene Symbols: BABAM2
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human BRCC45.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9577
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG