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Tocris Bioscience™ BRD 0539

Cell permeable and reversible Cas9 inhibitor

Manufacturer:  Tocris Bioscience™ 7153/2

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Catalog No. 71-532

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BRD 0539 is a cell-permeable and reversible SpCas9 (Streptococcus pyogenes Cas9) inhibitor. BRD 0539 shows dose-dependent SpCas9 inhibition in an in vitro DNA cleavage assay (apparent IC50 = 22 μM) and in an eGFP disruption assay (apparent EC50 = 11 μM). Allows dose and temporal control of SpCas9-based systems.


(3 aR,4 R,9 bR)-8-(2-Fluorophenyl)-2,3,3 A,4,5,9 b-hexahydro-1-[(4-methylphenyl)sulfonyl]-1 H-pyrrolo[3,2-c]quinoline-4-methanol
CRISPR Reagents
2 mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at -20°C

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