BRD4 Rabbit anti-Human, Active Motif™

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-3868	Active Motif 91302	10 μg
50-199-3867	Active Motif 91301	100 μg

Description

BRD4, a ubiquitously expressed nuclear phosphoprotein, is a member of BET protein family. It is a human homolog of mouse MCAP and consists of 2 N-terminal bromodomains, a central ET-domain, and several kinase-like motifs in its N-terminus. It is expressed as 2 isoforms; the longer variant has a C-terminus region with a praline and glutamine-rich domains. BRD4 is a chromatin-binding protein whose expression is induced in response to growth stimuli. BRD4 acts at different stages of the cell cycle by interacting with proteins including RFC and SPA-1 and regulates cell growth. It also has a role in regulating chromosomal dynamics during mitosis. BRD4 functions as a cellular target for E2 protein of papillomavirus.

Specifications

• Antigen: BRD4
• Applications: ChIP sequencing (ChIP-seq)
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: O60885
• Gene ID (Entrez): 23476
• Immunogen: This antibody was raised against a recombinant protein comprising amino acids 149-284 of human BRD4.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: BRD4

• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 140mM HEPES, 32mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5
• Gene Alias: BOS_7204; Brd4; BRD4-NUT FUSION; Brd5; bromodomain containing 4; bromodomain-containing 4; bromodomain-containing 5; Bromodomain-containing protein 4; CAP; chromosome-associated protein; fsh-like protein; HUNK1; HUNKI; Mcap; Mitotic chromosome-associated protein; Protein HUNK1; WI-11513
• Gene Symbols: BRD4
• Isotype: IgG
• Purification Method: Protein A
• Product Type: Antibody